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Arachidyl amido cholanoic acid improves liver glucose and lipid homeostasis in nonalcoholic steatohepatitis via AMPK and mTOR regulation.
Fernández-Ramos D, Lopitz-Otsoa F, Delacruz-Villar L, Bilbao J, Pagano M, Mosca L, Bizkarguenaga M, Serrano-Macia M, Azkargorta M, Iruarrizaga-Lejarreta M, Sot J, Tsvirkun D, van Liempd SM, Goni FM, Alonso C, Martínez-Chantar ML, Elortza F, Hayardeny L, Lu SC, Mato JM. Fernández-Ramos D, et al. World J Gastroenterol. 2020 Sep 14;26(34):5101-5117. doi: 10.3748/wjg.v26.i34.5101. World J Gastroenterol. 2020. PMID: 32982112 Free PMC article.
BACKGROUND: Arachidyl amido cholanoic acid (Aramchol) is a potent downregulator of hepatic stearoyl-CoA desaturase 1 (SCD1) protein expression that reduces liver triglycerides and fibrosis in animal models of steatohepatitis. In a phase IIb clinical trial in patients with …
BACKGROUND: Arachidyl amido cholanoic acid (Aramchol) is a potent downregulator of hepatic stearoyl-CoA desaturase 1 (SCD1) protein expressi …
Genomic and Clinicopathologic Features of Primary Myelofibrosis With Isolated 13q Deletion.
Mehrotra M, Patel KP, Chen T, Miranda RN, Wang Y, Zuo Z, Muddasani R, Mishra BM, Abraham R, Luthra R, Lu G. Mehrotra M, et al. Clin Lymphoma Myeloma Leuk. 2015 Aug;15(8):496-505.e1-2. doi: 10.1016/j.clml.2015.03.018. Epub 2015 Apr 3. Clin Lymphoma Myeloma Leuk. 2015. PMID: 26027540
RESULTS: Clinicopathologically, del(13q) PMF patients had significantly higher blast counts (P = .03) than did NK patients, who had significantly higher marrow cellularity (P = .02). The degree of bone marrow fibrosis of PMF-3 was higher in the del(13q) group than in the N …
RESULTS: Clinicopathologically, del(13q) PMF patients had significantly higher blast counts (P = .03) than did NK patients, who had signific …